Curcumin improves synaptic plasticity impairment induced by HIV-1gp120 V3 loop

Autor: Ling-ling Shen, Ming-liang Jiang, Si-si Liu, Min-chun Cai, Zhong-qiu Hong, Li-qing Lin, Yan-yan Xing, Gui-lin Chen, Rui Pan, Li-juan Yang, Ying Xu, Jun Dong
Jazyk: angličtina
Rok vydání: 2015
Předmět:
microtubule
axon
kinesin-5
Eg5
regeneration
monastrol
molecular motor protein
aging
neurodegenerative disorders
telomere shortening
MSCs
cellular therapy
traumatic brain injury
spinal cord injuries
dual diagnosis
diagnosis
complications
rehabilitation
post-concussion syndrome
brain concussion
blood brain barrier
phage display
peptide library
nanocarrier
targeting
Schwann cells
neurite outgrowth
neuromuscular junction (NMJ)
multiple sclerosis
TGF-β/BMP-7/Smad signaling
myogenic differentiation
Trf3
tumor suppression
nerve regeneration
bone marrow mesenchymal stem cells
cerebral ischemia
tail vein injection
middle cerebral artery occlusion
cell therapy
neuroprotection
brain injury
neuroimaging
ferumoxytol
superparamagnetic iron oxide particles
human adipose-derived stem cells
intracerebral injection
magnetic resonance imaging
enhanced susceptibility-weighted angiography image
modified neurological severity scores
rats
Prussian blue staining
neural regeneration
non-invasive brain stimulation
transcranial magnetic stimulation
neurotrophic factor
brain-derived neurotrophic factor
neuroplasticity
hippocampus
cognitive function
curcumin
neurons
HIV-1 gp120 V3 loop
plasticity
HIV-associated neurocognitive disorders
output/input curve
long-term potentiation
excitatory postsynaptic potential
paired-pulse facilitation
Ca 2+
synaptosome
NSFC grants
Neurology. Diseases of the nervous system
RC346-429
Zdroj: Neural Regeneration Research, Vol 10, Iss 6, Pp 925-931 (2015)
Druh dokumentu: article
ISSN: 1673-5374
DOI: 10.4103/1673-5374.158358
Popis: Curcumin has been shown to significantly improve spatial memory impairment induced by HIV-1 gp120 V3 in rats, but the electrophysiological mechanism remains unknown. Using extracellular microelectrode recording techniques, this study confirmed that the gp120 V3 loop could suppress long-term potentiation in the rat hippocampal CA1 region and synaptic plasticity, and that curcumin could antagonize these inhibitory effects. Using a Fura-2/AM calcium ion probe, we found that curcumin resisted the effects of the gp120 V3 loop on hippocampal synaptosomes and decreased Ca 2+ concentration in synaptosomes. This effect of curcumin was identical to nimodipine, suggesting that curcumin improved the inhibitory effects of gp120 on synaptic plasticity, ameliorated damage caused to the central nervous system, and might be a potential neuroprotective drug.
Databáze: Directory of Open Access Journals
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