Successful anti-PD-1 therapy in metastatic endometrial cancer with microsatellite instability: a case report
| Autor: | T. T. Andabekov, M. K. Rodina, G. A. Raskin, K. G. Cham, I. O. Rutkin |
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| Jazyk: | ruština |
| Rok vydání: | 2019 |
| Předmět: | |
| Zdroj: | Опухоли женской репродуктивной системы, Vol 15, Iss 1, Pp 73-77 (2019) |
| Druh dokumentu: | article |
| ISSN: | 1994-4098 1999-8627 |
| DOI: | 10.17650/1994-4098-2019-15-1-73-77 |
| Popis: | High efficacy of anti-PD-1 therapy has been shown in malignant tumors with mismatch repair deficiency. According to the literature review, mismatch repair deficiency is determined in 20–40 % of all endometrial cancer cases and up to 48 % of its endometrioid subtype. We report the short review of the recent literature and the case of durable partial response on pembrolizumab immunotherapy in a patient with a metastatic endometrioid adenocarcinoma with MMR-deficiency progressed on 2 chemotherapy lines. Partial response was achieved after 6th course, treatment was stopped after 8th course. Patient is on follow-up without any anticancer treatment for 11 months. Partial response lasts for 13 months, with further reduction in tumor size. The treatment was well tolerated without adverse events. |
| Databáze: | Directory of Open Access Journals |
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