| Autor: |
R F Hanson, H L Sharp, G C Williams |
| Jazyk: |
angličtina |
| Rok vydání: |
1976 |
| Předmět: |
|
| Zdroj: |
Journal of Lipid Research, Vol 17, Iss 3, Pp 294-297 (1976) |
| Druh dokumentu: |
article |
| ISSN: |
0022-2275 |
| DOI: |
10.1016/S0022-2275(20)36990-X |
| Popis: |
An enzyme assay was developed to measure the conversion of the bile acid precursor, 3α, 7α, 12α-trihydroxy-5β-cholestan-26-oic acid (THCA), into cholic acid using homogenates of human liver biopsies. The average rate of metabolism of THCA into cholic acid was found to be 3.9 ± 0.5 (± 1 SD) pmoles of cholic acid formed/mg liver/minute in twelve normal liver biopsies. This assay system can be used to determine if the syndrome of neonatal cholestasis associated with a metabolic block in the conversion of THCA into cholic acid is transmitted as a genetic trait. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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