Impact of Extended Combination Antiretroviral Therapy on the Decline of HIV Prevalence in Pregnant Women in Malawi
| Autor: | Giuseppe Liotta MD, Frank Chimbwandira MD, Kristien Wouters MD, Karin Nielsen-Saines MD, MPH, Haswell Jere MD, Sandro Mancinelli MD, Susanna Ceffa PhD, Fulvio Erba MD, Leonardo Palombi MD, Maria Cristina Marazzi MD |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: | |
| Zdroj: | Journal of the International Association of Providers of AIDS Care, Vol 15 (2016) |
| Druh dokumentu: | article |
| ISSN: | 2325-9574 2325-9582 23259574 |
| DOI: | 10.1177/2325957415614643 |
| Popis: | Combination antiretroviral therapy has been shown to reduce HIV transmission and incident infections. In recent years, Malawi has significantly increased the number of individuals on combination antiretroviral drugs through more inclusive treatment policies. Using a retrospective observational cohort design, records with HIV test results were reviewed for pregnant women attending a referral hospital in Malawi over a 5-year period, with viral load measurements recorded. HIV prevalence over time was determined, and results correlated with population viral load. A total of 11 052 women were included in this analysis, with 440 (4.1%) HIV infections identified. HIV prevalence rates in pregnant women in Malawi halved from 6.4% to 3.0% over 5 years. Mean viral loads of adult patients decreased from 120 000 copies/mL to less than 20 000 copies/mL. Results suggest that community viral load has an effect on HIV incidence rates in the population, which in turn correlates with reduced HIV prevalence rates in pregnant women. |
| Databáze: | Directory of Open Access Journals |
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