Exposure to Fluoxetine induced Gonado-toxicity in female rats: Modulating role of Hybanthus enneaspermus
| Autor: | Muhammed A. Dikwa, Monsurat B. Falana, Muhammed R. Asinmi, Musbau A. Akanji, Quadri O. Nurudeen |
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| Jazyk: | angličtina |
| Rok vydání: | 2024 |
| Předmět: | |
| Zdroj: | The Proceedings of the Nigerian Academy of Science, Vol 17, Iss 1, Pp 68-78 (2024) |
| Druh dokumentu: | article |
| ISSN: | 0794-7976 2705-327X |
| DOI: | 10.57046/KMEF8268 |
| Popis: | Several scientific evidence supports the use of Hybanthus enneaspermus leaves in the management of female sexual inadequacies. Additionally, fluoxetine is a reproductive toxicant that induces sexual dysfunction. To determine the modulating role of aqueous extract of Hybanthus enneaspermus leaves on fluoxetine-induced gonado-toxicity, sixty healthy, sexually-responsive female rats (157.21 ± 6.89) were divided into six groups (A–F) comprising of 10 rats each. Group A (control group) were administered distilled water only, Group B-F received orally 15 mg/kg body weight (b.w) of fluoxetine prepared daily for 14 days for the induction of anti-oestrogenicity and subsequently received 0.5ml of distilled water, 20 mg/kg b.w of a reference drug (Tadalafil) and 0.5 mL equivalent to 250, 500 and 1000 mg/kg b.w of the extract respectively, orally, once daily (08:00-08:45h) for 7 days. Fluoxetine reduced serum oestrogen concentrations by 54.79% and significantly reduced (p |
| Databáze: | Directory of Open Access Journals |
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