| Autor: |
Aghilas Akkache, Lisa Clavier, Oleh Mezhenskyi, Kateryna Andriienkova, Thibaut Soubrié, Philippe Lavalle, Nihal Engin Vrana, Varvara Gribova |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
Advanced NanoBiomed Research, Vol 4, Iss 3, Pp n/a-n/a (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2699-9307 |
| DOI: |
10.1002/anbr.202300085 |
| Popis: |
In biomaterials development, creating materials with desirable properties can be a time‐consuming and resource‐intensive process, often relying on serendipitous discoveries. A potential route to accelerate this process is to employ artificial intelligence methodologies such as machine learning (ML). Herein, the possibility to predict anti‐inflammatory properties of the polymers by using a simplified model of inflammation and a restrained dataset is explored. Cellular assays with 50 different polymers are conducted using the murine macrophage cell line RAW 264.7 as a model. These experiments generate a dataset which is used to develop a ML model based on Bayesian logistic regression. After conducting a Bayesian logistic regression analysis, two ML models, K‐nearest neighbors (KNN) and Naïve Bayes, are employed to predict anti‐inflammatory polymers properties. The study finds that the probability of a polymer having anti‐inflammatory properties is multiplied by three if it is a polycation, and that nitric oxide secretion is a good indicator in determining the anti‐inflammatory properties of a polymer, which in this work are defined by tumor necrosis factor alpha expression decrease. Overall, the study suggests that with appropriate dataset design, ML techniques can provide valuable information on functional polymer properties, enabling faster and more efficient biomaterial development. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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