Dissolution Thermodynamics and Preferential Solvation of Phenothiazine in Some Aqueous Cosolvent Systems

Autor: Fleming Martínez, María Ángeles Peña, Abolghasem Jouyban
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Liquids, Vol 4, Iss 2, Pp 443-455 (2024)
Druh dokumentu: article
ISSN: 2673-8015
DOI: 10.3390/liquids4020024
Popis: Published equilibrium mole fraction solubilities of phenothiazine in ethanol, propylene glycol and water as mono-solvents at several temperatures were investigated to find standard apparent thermodynamic quantities of dissolution mixing and solvation based on the van’t Hoff and Gibbs equations. Further, by processing the reported mole fraction solubility values of phenothiazine in some aqueous cosolvent mixtures at T/K = 298.2, the inverse Kirkwood–Buff integrals treatment demonstrated preferential hydration of phenothiazine in water-rich mixtures and preferential solvation of this agent by cosolvents in mixtures of 0.24 < x1 < 1.00 in the {ethanol (1) + water (2)} mixed system and mixtures of 0.18 < x1 < 1.00 in the {propylene glycol (1) + water (2)} mixed system.
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