| Autor: |
Andrés Ricardo Pérez-Riera, Luiz Carlos de Abreu, Raimundo Barbosa-Barros, José Grindler, Acácio Fernandes-Cardoso, Adrian Baranchuk |
| Jazyk: |
angličtina |
| Rok vydání: |
2016 |
| Předmět: |
|
| Zdroj: |
Indian Pacing and Electrophysiology Journal, Vol 16, Iss 4, Pp 126-133 (2016) |
| Druh dokumentu: |
article |
| ISSN: |
0972-6292 |
| DOI: |
10.1016/j.ipej.2016.10.002 |
| Popis: |
P-wave dispersion (PWD, Pd or Pdis) is a noninvasive electrocardiographic (ECG) marker for atrial remodeling and predictor for atrial fibrillation (AF). PWD is defined as the difference between the widest and the narrowest P-wave duration recorded from the 12 ECG leads. Increased P-wave duration and PWD reflect prolongation of intraatrial and interatrial conduction time with lack of a well-coordinated conduction system within the atrial muscles, with inhomogeneous, asynchronic, pro-inflammatory and anti-inflammatory effect mediated by interleukin-6 (IL-6) in patients with the CG + GG genotype IL-6 -634C/G polymorphism [1] and discontinuous propagation of sinus impulses mainly between the left and right atria, interstitial/extracellular fibroblast activation and collagen deposition with fibrosis (via TGF-β) in atrial tissue, insufficient blood supply, significant not isotropic myoelectric activity, and thin wall thickness and consequent expansion tendency all well-known electrophysiological characteristics in patients with atrial arrhythmias and especially paroxysmal atrial fibrillation (PAF) [2]. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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