| Autor: |
Zhiyuan Xie, Linghao Wang, Yan Zhang |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Global Medical Genetics, Vol 09, Iss 04, Pp 268-276 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2699-9404 |
| DOI: |
10.1055/s-0042-1756662 |
| Popis: |
Organoids are powerful systems to facilitate the study of individuals' disorders and personalized treatments because they mimic the structural and functional characteristics of organs. However, the full potential of organoids in research has remained unrealized and the clinical applications have been limited. One of the reasons is organoids are most efficient grown in reconstituted extracellular matrix hydrogels from mouse-derived, whose poorly defined, batch-to-batch variability and immunogenicity. Another reason is that organoids lack host conditions. As a component of the tumor microenvironment, microbiota and metabolites can regulate the development and treatment in several human malignancies. Here, we introduce several engineering matrix materials and review recent advances in the coculture of organoids with microbiota and their metabolites. Finally, we discuss current trends and future possibilities to build more complex cocultures. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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