A dual action of alpha-lipoic acid in the brain: an electrophysiological evaluation

Autor: Otoni Cardoso do Vale, Daniel Sá Roriz Fonteles, Francisco Romero Cabral, Manassés Claudino Fonteles
Jazyk: angličtina
Rok vydání: 2003
Předmět:
Zdroj: Arquivos de Neuro-Psiquiatria, Vol 61, Iss 3B, Pp 738-745 (2003)
Druh dokumentu: article
ISSN: 1678-4227
Popis: Oxidative stress causes metabolic and structural abnormalities during reperfusion. In an animal model of electrophysiological evaluation of cerebral ischemia-reperfusion, alpha-lipoic acid effect on the oxidative stress was studied by mean absolute amplitude of EEG spectra evaluation. The left carotideal infusion of 3.03 mM alpha-lipoic acid in Wistar rats after cerebral ischemia and reperfusion caused initial reduction and partial final recuperation of the various EEG spectral frequency mean absolute amplitudes (p
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