| Autor: |
Yoko Shigemoto, Daichi Sone, Miho Ota, Norihide Maikusa, Masayo Ogawa, Kyoji Okita, Harumasa Takano, Koichi Kato, Yukio Kimura, Emiko Morimoto, Fumio Suzuki, Hiroyuki Fujii, Noriko Sato, Hiroshi Matsuda |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Předmět: |
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| Zdroj: |
EJNMMI Research, Vol 9, Iss 1, Pp 1-5 (2019) |
| Druh dokumentu: |
article |
| ISSN: |
2191-219X |
| DOI: |
10.1186/s13550-019-0552-3 |
| Popis: |
Abstract Backgrounds Although neurofibrillary tangles (NFTs) mainly accumulate in the medial temporal lobe with human aging, only a few imaging studies have investigated correlations between NFT accumulation and gray matter (GM) volume in cognitively normal older adults. Here, we investigated the correlations between 18F-THK5351 accumulation and GM volume at the voxel level. Material and methods We recruited 47 amyloid-negative, cognitively normal, older adults (65.0 ± 7.9 years, 26 women), who underwent structural magnetic resonance imaging, 11C-Pittsburgh compound-B and 18F-THK5351 PET scans, and neuropsychological assessment. The magnetic resonance and 18F-THK5351 PET images were spatially normalized using Statistical Parametric Mapping 12. Voxel-wise correlations between 18F-THK5351 accumulation and GM volume were evaluated using the Biological Parametric Mapping toolbox. Results A significant negative correlation (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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