A comparative genomics methodology reveals a widespread family of membrane-disrupting T6SS effectors

Autor: Chaya M. Fridman, Kinga Keppel, Motti Gerlic, Eran Bosis, Dor Salomon
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-020-14951-4
Popis: Gram-negative bacteria deliver effectors via the type VI secretion system (T6SS) to outcompete their rivals. Here, Fridman et al. present an approach to identify T6SS effectors encoded in bacterial genomes without prior knowledge of their domain content or genetic neighbourhood, and identify a new family of membrane-disrupting effectors.
Databáze: Directory of Open Access Journals