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Rie Urabe,1 Toru Hachisuga,1 Taeko Ueda,1 Toshinori Kawagoe,1 Tomoko Kurita,1 Seiji Kagami,1 Masanori Hisaoka,2 Yoshihisa Fujino3 1Department of Obstetrics and Gynecology, 2Department of Pathology and Oncology, 3Department of Preventive Medicine and Community Health, School of Medicine, University of Occupational and Environmental Health, Iseigaoka, Yahatanishi-ku, Kitakyushu, Japan Objectives: Age-related changes in the expression of hormonal receptors have not been well examined in the fallopian tube (FT). We herein report the effect of menopause on the hormone receptors in ampullae of the FTs (AFTs), in comparison with cortical inclusion cysts (CICs) of the ovary.Methods: A total of 84 AFTs and 16 fimbriae of FTs, which were obtained from 26 premenopausal and 58 postmenopausal women; and 27 postmenopausal CICs were immunohistochemically studied for the expression of p53, Ki-67, estrogen receptor-alpha (ER-α), and progesterone receptor A (PRA). Apoptotic cells were identified using a TUNEL assay.Results: Postmenopausal AFTs showed a significantly lower labeling index (LI) for Ki-67 (P |
