Suppressive activity of macrolide antibiotics on nitric oxide production by lipopolysaccharide stimulation in mice

Autor:	Hajime Terao, Kazuhito Asano, Ken-ichi Kanai, Yoshiyuki Kyo, So Watanabe, Tadashi Hisamitsu, Harumi Suzaki
Jazyk:	angličtina
Rok vydání:	2003
Předmět:	Macrolide antibiotics Nitric oxide Mouse Inducible nitric oxide synthase mRNA Pro-inflammatory cytokine Suppression In vivo. Pathology RB1-214
Zdroj:	Mediators of Inflammation, Vol 12, Iss 4, Pp 195-202 (2003)
Druh dokumentu:	article
ISSN:	0962-9351 1466-1861 80411487
DOI:	10.1080/09629350310001599620
Popis:	Background and aim: Low-dose and long-term administration of macrolide antibiotics into patients with chronic airway inflammatory diseases could favorably modify their clinical conditions. However, the therapeutic mode of action of macrolides is not well understood. Free oxygen radicals, including nitric oxide (NO), are well recognized as the important final effector molecules in the development and the maintenance of inflammatory diseases.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/343d040a3f804114872ca450b7f125b9 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF