Decreased telomere length in the small airway epithelium suggests accelerated aging in the lungs of persons living with human immunodeficiency virus (HIV)

Autor:	Stella Xu, Emily A. Vucic, Tawimas Shaipanich, Stephen Lam, Wan Lam, Julio S. Montaner, Don D. Sin, S. F. Paul Man, Janice M. Leung
Jazyk:	angličtina
Rok vydání:	2018
Předmět:	HIV Telomere length Epithelial cell Diseases of the respiratory system RC705-779
Zdroj:	Respiratory Research, Vol 19, Iss 1, Pp 1-4 (2018)
Druh dokumentu:	article
ISSN:	1465-993X
DOI:	10.1186/s12931-018-0821-0
Popis:	Abstract Human immunodeficiency virus (HIV) infection is associated with an increased risk of chronic obstructive pulmonary disease (COPD) independent of cigarette smoke exposure. Previous studies have demonstrated that decreased peripheral leukocyte telomere length is associated with HIV, suggesting an accelerated aging phenomenon. We demonstrate that this process of telomere shortening also occurs in the lungs, with significant decreases in telomere length observed in small airway epithelial cells collected during bronchoscopy. Molecular evidence of accelerated aging in the small airway epithelium of persons living with HIV may be one clue into the predisposition for chronic lung disease observed in this population.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/343b232075ed407f81ffddffc45240ed Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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