Increased apolipoprotein E and decreased TNF‐α in the cerebrospinal fluid of nondemented APOE‐ε4 carriers

Autor:	Daimei Sasayama, Kotaro Hattori, Yuuki Yokota, Ryo Matsumura, Toshiya Teraishi, Sumiko Yoshida, Hiroshi Kunugi
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	alzheimer disease apolipoproteins E biomarkers cerebrospinal fluid proteins tumor necrosis factor‐alpha Therapeutics. Pharmacology RM1-950 Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Zdroj:	Neuropsychopharmacology Reports, Vol 40, Iss 2, Pp 201-205 (2020)
Druh dokumentu:	article
ISSN:	2574-173X
DOI:	10.1002/npr2.12110
Popis:	Abstract Aim The ε4 allele of apolipoprotein E gene (APOE) is a well‐known risk factor of late‐onset Alzheimer's disease. However, little is known why this variant confers a risk for Alzheimer's disease. The aim of this study was to examine the influence of the APOE genotype on cerebrospinal fluid (CSF) protein levels. Methods The present study performed a secondary analysis on our previously generated database to compare the CSF levels of 1128 proteins between APOE‐ε4 carriers (28 subjects) and noncarriers (104 subjects). All subjects were physically healthy Japanese individuals without dementia. Results CSF levels of apoE2, apoE3, and apoE4 were significantly higher (all nominal P
Databáze:	Directory of Open Access Journals
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