Hepatic steatosis with significant fibrosis is associated with an increased 10-year estimated risk of cardiovascular disease in adults with type 1 diabetes mellitus

Autor:	Alessandro Mantovani, Mario Luca Morieri, Luisa Palmisano, Maria Masulli, Efisio Cossu, Marco Giorgio Baroni, Katia Bonomo, Flavia Agata Cimini, Gisella Cavallo, Raffaella Buzzetti, Carmen Mignogna, Frida Leonetti, Simonetta Bacci, Roberto Trevisan, Riccardo Maria Pollis, Raffaella Aldigeri, Alessandra Dei Cas, Saula Vigili de Kreutzenberg, Giovanni Targher
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	NAFLD Non-alcoholic fatty liver disease T1DM Type 1 diabetes CVD Cardiovascular disease Diseases of the circulatory (Cardiovascular) system RC666-701
Zdroj:	Cardiovascular Diabetology, Vol 22, Iss 1, Pp 1-12 (2023)
Druh dokumentu:	article
ISSN:	1475-2840
DOI:	10.1186/s12933-023-01945-x
Popis:	Abstract Background We assessed whether hepatic steatosis with or without significant fibrosis (determined by validated non-invasive biomarkers) is associated with an increased 10-year estimated risk for cardiovascular disease (CVD) in people with type 1 diabetes mellitus (T1DM). Methods We conducted a retrospective, multicenter, cross-sectional study involving 1,254 adults with established T1DM without pre-existing CVD. We used the hepatic steatosis index (HSI) and fibrosis (FIB)-4 index for non-invasively detecting hepatic steatosis (defined as HSI > 36), with or without coexisting significant fibrosis (defined as FIB-4 index ≥ 1.3 or
Databáze:	Directory of Open Access Journals
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