Influence of clinical factors on the protective or deleterious impact of genetic variants in orthodontically induced external root resorption: an observational study

Autor: Henriqueta Coimbra Silva, Nuno Lavado, Filomena Canova, Miguel Guevara Lopez, Fernando J. Regateiro, Sónia A. Pereira
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: BMC Oral Health, Vol 22, Iss 1, Pp 1-8 (2022)
Druh dokumentu: article
ISSN: 1472-6831
DOI: 10.1186/s12903-022-02306-y
Popis: Abstract Background Prediction of susceptibility to Orthodontically Induced External Apical Root Resorption (OIEARR) has been hampered by the complex architecture of this multifactorial phenotype. The aim of this study was to analyze the impact of the interaction of multiple variables in the susceptibility to OIEARR. Methods The study evaluated 195 patients requiring orthodontic treatment. Nine clinical and treatment variables, single nucleotide polymorphisms (SNPs) from five genes and variables interactions were analyzed as risk factors for OIEARR using a multiple linear regression model. Results The model explained 29% of OIEARR variability (ANOVA: p
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