Deep neuromuscular block reduces the incidence of intra-operative complications during laparoscopic donor nephrectomy: a pooled analysis of randomized controlled trials

Autor: Gabby T. J. A. Reijnders-Boerboom, Esmee V. van Helden, Robert C. Minnee, Kim I. Albers, Moira H. D. Bruintjes, Albert Dahan, Chris H. Martini, Frank C. H. d’Ancona, Gert-Jan Scheffer, Christiaan Keijzer, Michiel C. Warlé
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Perioperative Medicine, Vol 10, Iss 1, Pp 1-9 (2021)
Druh dokumentu: article
ISSN: 2047-0525
DOI: 10.1186/s13741-021-00224-1
Popis: Abstract Study objective To assess whether different intensities of intra-abdominal pressure and deep neuromuscular blockade influence the risk of intra-operative surgical complications during laparoscopic donor nephrectomy. Design A pooled analysis of ten previously performed prospective randomized controlled trials. Setting Laparoscopic donor nephrectomy performed in four academic hospitals in the Netherlands: Radboudumc, Leiden UMC, Erasmus MC Rotterdam, and Amsterdam UMC. Patients Five hundred fifty-six patients undergoing a transperitoneal, fully laparoscopic donor nephrectomy enrolled in ten prospective, randomized controlled trials conducted in the Netherlands from 2001 to 2017. Interventions Moderate (tetanic count of four > 1) versus deep (post-tetanic count 1–5) neuromuscular blockade and standard (≥10 mmHg) versus low (
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