Profiling the neuroimmune cascade in 3xTg-AD mice exposed to successive mild traumatic brain injuries

Autor:	Alyssa F. Pybus, Sara Bitarafan, Rowan O. Brothers, Alivia Rohrer, Arushi Khaitan, Felix Rivera Moctezuma, Kareena Udeshi, Brae Davies, Sydney Triplett, Martin N. Griffin, Eric B. Dammer, Srikant Rangaraju, Erin M. Buckley, Levi B. Wood
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	Traumatic brain injury Mild traumatic brain injury Alzheimer’s pathology Cytokines Neuroinflammation MAPK Neurology. Diseases of the nervous system RC346-429
Zdroj:	Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-21 (2024)
Druh dokumentu:	article
ISSN:	1742-2094
DOI:	10.1186/s12974-024-03128-1
Popis:	Abstract Repetitive mild traumatic brain injuries (rmTBI) sustained within a window of vulnerability can result in long term cognitive deficits, depression, and eventual neurodegeneration associated with tau pathology, amyloid beta (Aβ) plaques, gliosis, and neuronal and functional loss. However, a comprehensive study relating acute changes in immune signaling and glial reactivity to neuronal changes and pathological markers after single and repetitive mTBIs is currently lacking. In the current study, we addressed the question of how repeated injuries affect the brain neuroimmune response in the acute phase of injury (
Databáze:	Directory of Open Access Journals
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