New Coordination Compounds Based on a Pyrazine Derivative: Design, Characterization, and Biological Study

Autor:	Alina Climova, Ekaterina Pivovarova, Bartłomiej Rogalewicz, Anita Raducka, Małgorzata Szczesio, Izabela Korona-Głowniak, Agnieszka Korga-Plewko, Magdalena Iwan, Katarzyna Gobis, Agnieszka Czylkowska
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	nickel(II) iron(III) cobalt(II) manganese(II) drug design pyrazine derivative Organic chemistry QD241-441
Zdroj:	Molecules, Vol 27, Iss 11, p 3467 (2022)
Druh dokumentu:	article
ISSN:	1420-3049
DOI:	10.3390/molecules27113467
Popis:	New coordination compounds of Mn(II), Fe(III), Co(II), and Ni(II) and the biologically active ligand L (N′-benzylidenepyrazine-2-carbohydrazonamide) were synthesized and characterized by appropriate analytical techniques: elemental analysis (EA), thermogravimetric analysis (TG–DTG), infrared spectroscopy (FTIR), and flame-atomic absorption spectrometry (F-AAS). The biological activity of the obtained compounds was then comprehensively investigated. Rational use of these compounds as potential drugs was proven by ADME analysis. All obtained compounds were screened in vitro for antibacterial, antifungal, and anticancer activities. Some of the studied complexes exhibited significantly higher activity than the ligand alone.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/33f9513b10344f86a6cee6259b88c49a Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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