Physical Activity and Incident Heart Failure in High‐Risk Subgroups: The ARIC Study

Autor: Roberta Florido, Lucia Kwak, Mariana Lazo, Erin D. Michos, Vijay Nambi, Roger S. Blumenthal, Gary Gerstenblith, Priya Palta, Stuart D. Russell, Christie M. Ballantyne, Elizabeth Selvin, Aaron R. Folsom, Josef Coresh, Chiadi E. Ndumele
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 9, Iss 10 (2020)
Druh dokumentu: article
ISSN: 2047-9980
DOI: 10.1161/JAHA.119.014885
Popis: Background Greater physical activity (PA) is associated with lower heart failure (HF) risk. However, it is unclear whether this inverse association exists across all subgroups at high risk for HF, particularly among those with preexisting atherosclerotic cardiovascular disease. Methods and Results We followed 13 810 ARIC (Atherosclerosis Risk in Communities) study participants (mean age 55 years, 54% women, 26% black) without HF at baseline (visit 1; 1987–1989). PA was assessed using a modified Baecke questionnaire and categorized according to American Heart Association guidelines: recommended, intermediate, or poor. We constructed Cox models to estimate associations between PA categories and incident HF within each high‐risk subgroup at baseline, with tests for interaction. We performed additional analyses modeling incident coronary heart disease as a time‐varying covariate. Over a median of 26 years of follow‐up, there were 2994 HF events. Compared with poor PA, recommended PA was associated with lower HF risk among participants with hypertension, obesity, diabetes mellitus, and metabolic syndrome (all P
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