Association of elevated circulating monocyte-platelet aggregates with hypercoagulability in patients with nephrotic syndrome

Autor: Shi-Ping Na, Mei-Liang Ning, Ji-Fang Ma, Shuang Liang, Yan-Li Wang, Man-Shu Sui, Xiao-Fang Guo, Ying Ji, Hui-Yan Lyu, Xue-Ying Yuan, Yu-Shi Bao
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Thrombosis Journal, Vol 22, Iss 1, Pp 1-7 (2024)
Druh dokumentu: article
ISSN: 1477-9560
DOI: 10.1186/s12959-024-00626-3
Popis: Abstract Background Hypercoagulability emerges as a central pathological feature and clinical complication in nephrotic syndrome. Increased platelet activation and aggregability are closely related to hypercoagulability in nephrotic syndrome. Monocyte-platelet aggregates (MPAs) have been proposed to represent a robust biomarker of platelet activation. The aim of this study was to investigate levels of the circulating MPAs and MPAs with the different monocyte subsets to evaluate the association of MPAs with hypercoagulability in nephrotic syndrome. Methods Thirty-two patients with nephrotic syndrome were enrolled. In addition, thirty-two healthy age and sex matched adult volunteers served as healthy controls. MPAs were identified by CD14 monocytes positive for CD41a platelets. The classical (CD14 + + CD16-, CM), the intermediate (CD14 + + CD16+, IM) and the non-classical (CD14 + CD16++, NCM) monocytes, as well as subset specific MPAs, were measured by flow cytometry. Results Patients with nephrotic syndrome showed a higher percentage of circulating MPAs as compared with healthy controls (p
Databáze: Directory of Open Access Journals
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje