Botulinum Neurotoxin Injections in Childhood Opisthotonus

Autor: Mariam Hull, Mered Parnes, Joseph Jankovic
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Toxins, Vol 13, Iss 2, p 137 (2021)
Druh dokumentu: article
ISSN: 13020137
2072-6651
DOI: 10.3390/toxins13020137
Popis: Opisthotonus refers to abnormal axial extension and arching of the trunk produced by excessive contractions of the paraspinal muscles. In childhood, the abnormal posture is most often related to dystonia in the setting of hypoxic injury or a number of other acquired and genetic etiologies. The condition is often painful, interferes with ambulation and quality of life, and is challenging to treat. Therapeutic options include oral benzodiazepines, oral and intrathecal baclofen, botulinum neurotoxin injections, and deep brain stimulation. Management of opisthotonus within the pediatric population has not been systematically reviewed. Here, we describe a series of seven children who presented to our institution with opisthotonus in whom symptom relief was achieved following administration of botulinum neurotoxin injections.
Databáze: Directory of Open Access Journals
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