Current research and evidence gaps on placental development in iron deficiency anemia

Autor: Lai Shaoyang, Yu Weiwei, Liu Ying, Yang Yuxin, Zhang Xueqin
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Open Life Sciences, Vol 19, Iss 1, Pp e28918-840 (2024)
Druh dokumentu: article
ISSN: 2391-5412
DOI: 10.1515/biol-2022-0827
Popis: Studying the effects of maternal iron deficiency anemia (IDA) is complex owing to its diverse causes, each independently impacting the placenta and fetus. Simple treatment with iron supplements does not always resolve the anemia. Therefore, delving into how IDA alters placental development at a molecular level is crucial to further optimize treatment. This review addresses the effects of IDA on placental structures and functions, including changes in oxygen levels, blood vessels, and the immune system. Profound understanding of physiological characteristics and regulatory mechanisms of placental development is key to explain the mechanisms of abnormal placental development in pregnancy-associated disorders. In turn, future strategies for the prevention and treatment of pregnancy complications involving the placenta can be devised. These studies are significant for improving human reproductive health, enhancing sociodemographic qualities, and even lifelong wellbeing, a focal point in future placental research.
Databáze: Directory of Open Access Journals