Effects of multiple fluid intake on Urolithiasis by mendelian randomization study

Autor:	Qian Zhang, Zedan Guo, JinYuan Zhang, Hang Liu, Li Yi
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	Fluid intake Urinary calculi Beverages Mendelian randomization UK Biobank FinnGen Medicine Science
Zdroj:	Scientific Reports, Vol 14, Iss 1, Pp 1-8 (2024)
Druh dokumentu:	article
ISSN:	2045-2322
DOI:	10.1038/s41598-024-73891-x
Popis:	Abstract Urolithiasis, a common and recurrent condition, imposes a significant global health burden. This study investigates the causal relationship between various types of fluid intake and urolithiasis using univariable and multivariable Mendelian randomization (MR) approaches. Genetic data for urolithiasis were obtained from the FinnGen Consortium (n = 400,681), while genetic measures for nine fluid types were sourced from meta-analyses of genome-wide association studies (GWAS). The analysis revealed that genetically predicted coffee intake (OR: 0.571, 95% confidence interval (CI): 0.341–0.958, p = 0.034) and ground coffee intake (OR: 0.219, 95% CI: 0.005–0.923, p = 0.038) were protective factors for upper urinary calculi. Additionally, a standard deviation (SD) increase in tea intake was associated with a 53% reduction in risk (OR: 0.473, 95% CI: 0.320–0.700, p
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/33d48d8f78c0494f8dbafb3e0af9b066 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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