| Autor: |
Natalia P. Machado, Edgard Torres dos Reis Neto, Maria Roberta M.P. Soares, Daniele S. Freitas, Adriana Porro, Rozana M. Ciconelli, Marcelo M. Pinheiro |
| Jazyk: |
angličtina |
| Rok vydání: |
2013 |
| Předmět: |
|
| Zdroj: |
Clinics, Vol 68, Iss 9, Pp 1189-1196 (2013) |
| Druh dokumentu: |
article |
| ISSN: |
1980-5322 |
| DOI: |
10.6061/clinics/2013(09)03 |
| Popis: |
OBJECTIVE: We evaluated the incidence of and the main risk factors associated with cutaneous adverse events in patients with chronic inflammatory arthritis following anti-TNF-α therapy. METHODS: A total of 257 patients with active arthritis who were taking TNF-α blockers, including 158 patients with rheumatoid arthritis, 87 with ankylosing spondylitis and 12 with psoriatic arthritis, were enrolled in a 5-year prospective analysis. Patients with overlapping or other rheumatic diseases were excluded. Anthropometric, socioeconomic, demographic and clinical data were evaluated, including the Disease Activity Score-28, Bath Ankylosing Spondylitis Disease Activity Index and Psoriasis Area Severity Index. Skin conditions were evaluated by two dermatology experts, and in doubtful cases, skin lesion biopsies were performed. Associations between adverse cutaneous events and clinical, demographic and epidemiological variables were determined using the chi-square test, and logistic regression analyses were performed to identify risk factors. The significance level was set at p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
