Diagnostic value of miR-92a in asymptomatic carotid artery stenosis patients and its ability to predict cerebrovascular events

Autor: Gang Chen, Jianwei Gao, Yuguo Sheng, Xinqiang Han, Xingang Ji, Mengpeng Zhao, Jian Wu
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Diagnostic Pathology, Vol 15, Iss 1, Pp 1-8 (2020)
Druh dokumentu: article
ISSN: 1746-1596
DOI: 10.1186/s13000-020-00987-z
Popis: Abstract Background Early diagnosis of asymptomatic carotid artery stenosis (ACAS) is important to prevent the incidence of cerebrovascular events. This study aimed to investigate the circulating expression of microRNA-92a (miR-92a) in ACAS patients and evaluate its diagnostic value for ACAS and predictive value for cerebrovascular events. Methods Circulating expression of miR-92a was measured using quantitative real-time PCR. Chi-square test was used to analyze the association of miR-92a with ACAS patients’ clinical characteristics. A receiver operating characteristic (ROC) was used to evaluate the diagnostic value of miR-92a, and the Kaplan-Meier method and Cox regression analysis were used to assess the predictive value of miR-92a for cerebrovascular events. Results Serum expression of miR-92a was higher in ACAS patients than that in the healthy controls (P
Databáze: Directory of Open Access Journals
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