| Autor: |
Hong Tham Pham, Tuong-Anh Mai-Phan, Anh Kiet Vu, Thi Ha Truong, Minh-Hoang Tran |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
BMJ Open, Vol 13, Iss 6 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2044-6055 |
| DOI: |
10.1136/bmjopen-2022-070489 |
| Popis: |
Objectives This study investigated remdesivir’s clinical use to provide direct evidence of effectiveness for a low-middle income Asian setting.Design A one-to-one propensity score matching retrospective cohort study.Setting A tertiary hospital with COVID-19 treatment facilities in Vietnam.Participants A total of 310 patients in standard of care (SoC) group were matched with 310 patients in SoC+remdesivir (SoC+R) group.Primary and secondary outcome measures The primary outcome was time to critical progression, defined as all-cause mortality or critical illness. The secondary outcomes were length of oxygen therapy/ventilation and need for invasive mechanical ventilation. Outcome reports were presented as HR, OR or effect difference with 95% CI.Results Patients receiving remdesivir had a lower risk for mortality or critical illness (HR=0.68, 95% CI 0.47 to 0.96, p=0.030). Remdesivir was not associated with a shorter length of oxygen therapy/ventilation (effect difference −0.17 days, 95% CI −1.29 to 0.96, p=0.774). The need for invasive mechanical ventilation was lower in SoC+R group (OR=0.57, 95% CI 0.38 to 0.86, p=0.007).Conclusions This study’s results showing remdesivir’s benefits in non-critical patients with COVID-19 may be extrapolated to other similar low-middle income countries, allowing more regimens for limited resource areas and reducing poor outcomes and equity gap worldwide. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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