COVID-19 during pregnancy should we really worry from vertical transmission or rather from fetal hypoxia and placental insufficiency? A systematic review

Autor: Antoine AbdelMassih, Raghda Fouda, Rana Essam, Alhussein Negm, Dalia Khalil, Dalia Habib, George Afdal, Habiba-Allah Ismail, Hadeer Aly, Ibrahim Genedy, Layla El Qadi, Leena Makki, Maha Shulqamy, Maram Hanafy, Marian AbdelMassih, Marina Ibrahim, Mohamed Ebaid, Monica Ibrahim, Nadine El-Husseiny, Nirvana Ashraf, Noura Shebl, Rahma Menshawey, Rama Darwish, Rana ElShahawi, Rana Ramadan, Sadra Albala, Salwa Imran, Sama Ahmed, Samer Khaldi, Sara Abohashish, Stavro Paulo, Yasmin Omar, Mourad Alfy Tadros
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Egyptian Pediatric Association Gazette, Vol 69, Iss 1, Pp 1-13 (2021)
Druh dokumentu: article
ISSN: 2090-9942
DOI: 10.1186/s43054-021-00056-0
Popis: Abstract Background COVID-19 is the largest outbreak to strike humanity. The wide scale of fatalities and morbidities lead to a concurrent pandemic of uncertainty in scientific evidence. Conflicting evidences are released on daily basis about the neonatal outcomes of COVID-19-positive mothers. The aim of this study was to use the relevant case reports and series to determine the percentage of newborns who test positive for COVID-19 who are born to COVID-19-positive mothers. Secondary outcomes included examining laboratory abnormalities among COVID-19-positive neonates, and any depicted placental abnormalities in COVID-19-positive mothers. For this purpose, systematic review was performed on all studies reporting primary data on fetus-mother pairs with COVID-19. Data bases were searched for studies that met our inclusion and exclusion criteria. Results Final screening revealed 67 studies, from which the primary data of 1787 COVID-19 mothers were identified and had their pregnancy outcome analyzed. Only 2.8% of infants born to COVID-19-positive mothers tested positive, and this finding is identical to percentages reported in former Coronaviridae outbreaks, whereas 20% manifested with intrauterine hypoxia alongside placental abnormalities suggestive of heavy placental vaso-occlusive involvement. Conclusions These findings suggest that while vertical transmission is unlikely, there appears to be an underlying risk of placental insufficiency due to the prothrombotic tendency observed in COVID-19 infection. Guidelines for proper prophylactic anticoagulation in COVID-positive mothers need to be established.
Databáze: Directory of Open Access Journals
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