Test–retest reliability and follow‐up of muscle magnetic resonance elastography in adults with and without muscle diseases

Autor: Bram De Wel, Lotte Huysmans, Ronald Peeters, Stefan Ghysels, Kris Byloos, Guido Putzeys, Frederik Maes, Patrick Dupont, Kristl G. Claeys
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Journal of Cachexia, Sarcopenia and Muscle, Vol 15, Iss 5, Pp 1761-1771 (2024)
Druh dokumentu: article
ISSN: 2190-6009
2190-5991
DOI: 10.1002/jcsm.13528
Popis: Abstract Background We investigated the potential of magnetic resonance elastography (MRE) stiffness measurements in skeletal muscles as an outcome measure, by determining its test–retest reliability, as well as its sensitivity to change in a longitudinal follow‐up study. Methods We assessed test–retest reliability of muscle MRE in 20 subjects with (n = 5) and without (n = 15) muscle diseases and compared this to Dixon proton density fat fraction (PDFF) and volume measurements. Next, we measured MRE muscle stiffness in 21 adults with Becker muscular dystrophy (BMD) and 21 age‐matched healthy controls at baseline, and after 9 and 18 months. We compared two different methods of analysing MRE data in this study: ‘Method A’ used the stiffness maps generated by the Philips MRE software, and ‘Method B’ applied a custom‐made procedure based on wavelength measurements on the MRE images. Results Intraclass correlation coefficients (ICC) of muscle stiffness ranged from good (0.83 for left vastus medialis, P 0.050 for all). The ICC of muscle PDFF and volume measurements was excellent (>0.90; P
Databáze: Directory of Open Access Journals