Comparison of mucin-1 in human breast cancer and canine mammary gland tumor: a review study

Autor:	Rana Vafaei, Mitra Samadi, Aysooda Hosseinzadeh, Khadijeh Barzaman, MohammadReza Esmailinejad, Zohreh Khaki, Leila Farahmand
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	Mucin-1 Canine mammary tumor Preclinical trials Immunotherapy Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Cytology QH573-671
Zdroj:	Cancer Cell International, Vol 22, Iss 1, Pp 1-9 (2022)
Druh dokumentu:	article
ISSN:	1475-2867
DOI:	10.1186/s12935-021-02398-6
Popis:	Abstract Mucin-1 (MUC-1) is a transmembrane glycoprotein, which bears many similarities between dogs and humans. Since the existence of animal models is essential to understand the significant factors involved in breast cancer mechanisms, canine mammary tumors (CMTs) could be used as a spontaneously occurring tumor model for human studies. Accordingly, this review assessed the comparison of canine and human MUC-1 based on their diagnostic and therapeutic aspects and showed how comparative oncology approaches could provide insights into translating pre-clinical trials from human to veterinary oncology and vice versa which could benefit both humans and dogs.
Databáze:	Directory of Open Access Journals
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