A comparative study of azithromycin and sulphadoxine-pyrimethamine as prophylaxis against malaria in pregnancy
| Autor: | Rukiyat Adeola Abdus-Salam, Folasade Adenike Bello, Fatai A Fehintola, Ayodele O Arowojolu |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: | |
| Zdroj: | Nigerian Postgraduate Medical Journal, Vol 23, Iss 2, Pp 57-61 (2016) |
| Druh dokumentu: | article |
| ISSN: | 1117-1936 2468-6875 |
| DOI: | 10.4103/1117-1936.186295 |
| Popis: | Context: The benefit of malaria prophylaxis in pregnancy is threatened by emergence of Plasmodium falciparum resistance to antimalarial agents for chemoprophylaxis and treatment. Aim: This study aimed to compare the effectiveness of azithromycin (AZ) with sulphadoxine-pyrimethamine (SP) for malaria prevention. Settings and Design: A prospective comparative study of antenatal clinic attendees at the University College Hospital, Ibadan, Nigeria. Participants were randomised to receive SP or AZ. Subjects and Methods: The subjects were antenatal attendees and Samples for malaria parasitaemia were collected and repeated at follow-up visits; maternal peripheral blood film, placental and cord blood samples were collected at delivery. Statistical Analysis Used: Chi-square test and t-test in a per-protocol analysis. Results: Of 200 participants (100 in each group), 166 (83.0%) completed the study: 86 (86.0%) of SP and 80 (80.0%) of AZ groups, respectively (P = 0.26). Four (4.7%) participants who had SP compared to five (6.2%) in AZ group developed malaria at mean gestational ages of 30.3 ± 1.56 and 33.0 ± 8.6, respectively (P = 0.56). Positive peripheral, placental and cord blood parasitaemia were found in ≤2% of the participants. Drug tolerability and foetal outcomes were comparable for both groups. Conclusion: AZ was comparable to SP for prevention of malaria in pregnancy and may be used in patients who do not tolerate SP. |
| Databáze: | Directory of Open Access Journals |
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