Hypertensive heart disease: Benefit of carvedilol in hemodynamic, left ventricular remodeling, and survival
| Autor: | Renata F Dominguez, Valeria A da Costa-Hong, Luan Ferretti, Fabio Fernandes, Luiz A Bortolotto, Fernanda M Consolim-Colombo, Brent M Egan, Heno F Lopes |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: | |
| Zdroj: | SAGE Open Medicine, Vol 7 (2019) |
| Druh dokumentu: | article |
| ISSN: | 2050-3121 20503121 |
| DOI: | 10.1177/2050312118823582 |
| Popis: | Objectives: The aim of this study was to determine if carvedilol improved structural and functional changes in the left ventricle and reduced mortality in patients with hypertensive heart disease. Methods: Blood pressure, heart rate, echocardiographic parameters, and laboratory variables, were assessed pre and post treatment with carvedilol in 98 eligible patients. Results: Carvedilol at a median dose of 50 mg/day during the treatment period in hypertensive heart disease lowered blood pressure 10/10 mmHg, heart rate 10 beats/min, improved left ventricular ejection fraction from baseline to follow-up (median: 6 years) (36%–47%)) and reduced left ventricular end-diastolic and end-systolic dimensions (62 vs 56 mm; 53 vs 42 mm, respectively, all p-values |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
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