Maternal undernutrition alters the skeletal muscle development and methylation of myogenic factors in goat offspring

Autor:	Xiaoling Zhou, Qiongxian Yan, Liling Liu, Genyuan Chen, Shaoxun Tang, Zhixiong He, Zhiliang Tan
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	dna methylation goat intrauterine undernutrition muscle fiber type myogenic factors Zoology QL1-991
Zdroj:	Animal Bioscience, Vol 35, Iss 6, Pp 847-857 (2022)
Druh dokumentu:	article
ISSN:	2765-0189 2765-0235
DOI:	10.5713/ab.21.0285
Popis:	Objective The effects of maternal undernutrition during midgestation on muscle fiber histology, myosin heavy chain (MyHC) expression, methylation modification of myogenic factors, and the mammalian target of rapamycin (mTOR) signaling pathway in the skeletal muscles of prenatal and postnatal goats were examined. Methods Twenty-four pregnant goats were assigned to a control (100% of the nutrients requirement, n = 12) or a restricted group (60% of the nutrients requirement, n = 12) between 45 and 100 days of gestation. Descendants were harvested at day 100 of gestation and at day 90 after birth to collect the femoris muscle tissue. Results Maternal undernutrition increased (p
Databáze:	Directory of Open Access Journals
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