Dietary restriction and the transcription factor clock delay eye aging to extend lifespan in Drosophila Melanogaster

Autor: Brian A. Hodge, Geoffrey T. Meyerhof, Subhash D. Katewa, Ting Lian, Charles Lau, Sudipta Bar, Nicole Y. Leung, Menglin Li, David Li-Kroeger, Simon Melov, Birgit Schilling, Craig Montell, Pankaj Kapahi
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-022-30975-4
Popis: Circadian dysfunction is a potential driver of eye aging. Here the authors report that in conjunction with the core molecular clock transcription factor Clock, dietary restriction promotes rhythmic homeostatic mechanisms within photoreceptors to delay visual senescence and extend lifespan in Drosophila Melanogaster.
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