FIBROSCLEROSIS AND SCLEROSING ADENOSIS WITH MICROCALCIFICATIONS IN THE BREAST. MOLECULAR PATHOGENESIS, TIMELY DIAGNOSIS AND TREATMENT
| Autor: | E. L. Muyzhnek, V. I. Kiselev, O. E. Jakobs, N. I. Rozhkova, A. D. Kaprin, I. I. Burdina, S. B. Zapirova, M. L. Mazo, S. P. Prokopenko, P. G. Labazanova |
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| Jazyk: | ruština |
| Rok vydání: | 2019 |
| Předmět: | |
| Zdroj: | Issledovaniâ i Praktika v Medicine, Vol 6, Iss 2, Pp 75-85 (2019) |
| Druh dokumentu: | article |
| ISSN: | 2410-1893 2409-2231 |
| DOI: | 10.17709/2409-2231-2019-6-2-8 |
| Popis: | A brief review of current data on the generality of the epidemiology and molecular pathogenesis of breast cancer and benign breast diseases is presented. Currently, a type of mastopathy, fibrosclerosis/sclerosing adenosis, accompanied by the formation of microcalcifications, is considered as a benign pathological condition with a high risk of malignancy, and also as a pre-start condition of a possible transition of mastopathy to cancer. In the review is discussed the fundamental biological process of the epithelial-mesenchymal transition (EMT) as a molecular pathogenetic basis of this phenomenon. Identification of the above mentioned pathological changes using mammography and refined diagnostics using a vacuum aspiration biopsy allow timely treatment of fibrosclerosis and sclerosing adenosis with Indinol® Forto, a drug of pathogenetic action based on indole-3-carbinol, due to its multiple anticancer and oncoprophylactic activity, including ability to reverse at the epigenetic level the EMT process abnormally proceeding in these benign breast diseases. |
| Databáze: | Directory of Open Access Journals |
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