White matter integrity is associated with cognition and amyloid burden in older adult Koreans along the Alzheimer’s disease continuum

Autor:	Lauren R. Hirschfeld, Rachael Deardorff, Evgeny J. Chumin, Yu-Chien Wu, Brenna C. McDonald, Sha Cao, Shannon L. Risacher, Dahyun Yi, Min Soo Byun, Jun-Young Lee, Yu Kyeong Kim, Koung Mi Kang, Chul-Ho Sohn, Kwangsik Nho, Andrew J. Saykin, Dong Young Lee, for the KBASE Research Group
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	Cingulum bundle of the hippocampus White matter Alzheimer’s disease Mild cognitive impairment Cognition Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Zdroj:	Alzheimer’s Research & Therapy, Vol 15, Iss 1, Pp 1-11 (2023)
Druh dokumentu:	article
ISSN:	1758-9193
DOI:	10.1186/s13195-023-01369-5
Popis:	Abstract Background White matter (WM) microstructural changes in the hippocampal cingulum bundle (CBH) in Alzheimer’s disease (AD) have been described in cohorts of largely European ancestry but are lacking in other populations. Methods We assessed the relationship between CBH WM integrity and cognition or amyloid burden in 505 Korean older adults aged ≥ 55 years, including 276 cognitively normal older adults (CN), 142 with mild cognitive impairment (MCI), and 87 AD patients, recruited as part of the Korean Brain Aging Study for the Early Diagnosis and Prediction of Alzheimer’s disease (KBASE) at Seoul National University. Results Compared to CN, AD and MCI subjects showed significantly higher RD, MD, and AxD values (all p-values
Databáze:	Directory of Open Access Journals
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