Interferonβ-1b Induces the Expression of RGS1 a Negative Regulator of G-Protein Signaling
| Autor: | Tiffany Tran, Pedro Paz, Sharlene Velichko, Jill Cifrese, Praveen Belur, Ken D. Yamaguchi, Karin Ku, Parham Mirshahpanah, Anthony T. Reder, Ed Croze |
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| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: | |
| Zdroj: | International Journal of Cell Biology, Vol 2010 (2010) |
| Druh dokumentu: | article |
| ISSN: | 1687-8876 1687-8884 |
| DOI: | 10.1155/2010/529376 |
| Popis: | We present evidence of a link between interferonβ-1b (IFN-β) and G-protein signaling by demonstrating that IFN-β can induce the expression of the negative regulator of G-protein signaling 1 (RGS1). RGS1 reduces G-protein activation and immune cell migration by interacting with heterotrimeric G-proteins and enhancing their intrinsic GTPase activity. In this study, IFN-β treatment resulted in the induction of RGS1 in peripheral blood mononuclear cells (PBMCs), monocytes, T cells, and B cells. Induction of RGS1 by IFN-β was concentration dependent and observed at both the RNA and protein level. Other members of the RGS family were not induced by IFN-β, and induction of RGS1 required the activation of the IFN receptor. In addition, RGS1 induction was observed in PBMCs obtained from IFN-β-treated multiple sclerosis patients suggesting a possible, as yet unexplored, involvement of G-protein regulation in disease treatment. The upregulation of RGS1 by IFN-β has not been previously reported. |
| Databáze: | Directory of Open Access Journals |
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