Risk of cardiac arrhythmia and cardiac arrest after primary and booster COVID-19 vaccination in England: A self-controlled case series analysis

Autor: Julia Stowe, Heather J. Whitaker, Nick J. Andrews, Elizabeth Miller FMedSci
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Vaccine: X, Vol 15, Iss , Pp 100418- (2023)
Druh dokumentu: article
ISSN: 2590-1362
DOI: 10.1016/j.jvacx.2023.100418
Popis: Background: Various cardiac arrhythmias have been reported after COVID-19 infection and vaccination. We assessed the risk after primary immunisation with the ChAdOx1 adenovirus vectored vaccine, and primary and booster immunisation with an mRNA vaccine in 40 million vaccinated adults with 121 million doses (33.9% ChAdOx1 and 66.1% mRNA) in England. Methods: Hospital admissions for a cardiac arrhythmia and emergency care attendance for a cardiac arrest in individuals aged 18 years and older on the 31st March 2021 were linked to the national COVID-19 immunisation register. The incidence of events 1–14 and 15–28 days after vaccination relative to a post-vaccination control period was estimated using the self-controlled case series method modified for fatal events. Outcomes were stratified by arrhythmia type, vaccine type, age group and dose number (up to five). Elevated relative incidence (RI) estimates with p
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