In mouse chronic pancreatitis CD25+FOXP3+ regulatory T cells control pancreatic fibrosis by suppression of the type 2 immune response

Autor: Juliane Glaubitz, Anika Wilden, Janine Golchert, Georg Homuth, Uwe Völker, Barbara M. Bröker, Thomas Thiele, Markus M. Lerch, Julia Mayerle, Ali A. Aghdassi, Frank U. Weiss, Matthias Sendler
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-022-32195-2
Popis: The function of T regulatory cells in the tissue fibrosis in chronic pancreatitis is not fully understood. Here the authors use a mouse model of chronic pancreatitis to show that Treg cells reduce IL-4 mediated chronic inflammation in the pancreas associated with M2-like macrophages in vivo.
Databáze: Directory of Open Access Journals