Nullity of GSTT1/GSTM1 related to pesticides is associated with Parkinson's disease
| Autor: | Marcela Augusta de Souza Pinhel, Caroline Leiko Sado, Gabriela dos Santos Longo, Michele Lima Gregorio, Gisele Sousa Amorim, Greiciane Maria da Silva Florim, Camila Montoro Mazeti, Denise Poltronieri Martins, Fabio de Nazare Oliveira, Marcelo Arruda Nakazone, Waldir Antonio Tognola, Doroteia Rossi Silva Souza |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: | |
| Zdroj: | Arquivos de Neuro-Psiquiatria, Vol 71, Iss 8, Pp 527-532 (2013) |
| Druh dokumentu: | article |
| ISSN: | 1678-4227 0004-282X |
| DOI: | 10.1590/0004-282X20130076 |
| Popis: | Genetic and environmental factors affect the pathogenesis of Parkinson's disease (PD). Genetic variants of the enzyme glutathione S-transferases (GST) may be related to the disease. This study aimed to evaluate the influence of genetic variants of GST (GSTT1/GSTM1) and their association with the exposure to environmental toxins in PD patients. We studied 254 patients with PD and 169 controls. The GSTM1/GSTT1 variants were analyzed by polymerase chain reaction. We applied the Fisher's exact test and the χ2 test for statistical analysis (p |
| Databáze: | Directory of Open Access Journals |
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