| Autor: |
Helen Tremlett, Feng Zhu, Douglas Arnold, Amit Bar‐Or, Charles N. Bernstein, Christine Bonner, Jessica D. Forbes, Morag Graham, Janace Hart, Natalie C. Knox, Ruth Ann Marrie, Ali I. Mirza, Julia O’Mahony, Gary Van Domselaar, E. Ann Yeh, Yinshan Zhao, Brenda Banwell, Emmanuelle Waubant, the US Network of Pediatric MS Centers, the Canadian Pediatric Demyelinating Disease Network |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Annals of Clinical and Translational Neurology, Vol 8, Iss 12, Pp 2252-2269 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2328-9503 |
| DOI: |
10.1002/acn3.51476 |
| Popis: |
Abstract Objective To examine the gut microbiota in individuals with and without pediatric‐onset multiple sclerosis (MS). Methods We compared stool‐derived microbiota of Canadian Pediatric Demyelinating Disease Network study participants ≤21 years old, with MS (disease‐modifying drug [DMD] exposed and naïve) or monophasic acquired demyelinating syndrome [monoADS] (symptom onset 0.1), taxa‐level and gut community networks did. MS (vs. monoADS) exhibited > fourfold higher relative abundance of the superphylum Patescibacteria (aRR = 4.2;95%CI:1.6–11.2, p = 0.004, Q = 0.01), and lower abundances of short‐chain fatty acid (SCFA)‐producing Lachnospiraceae (Anaerosporobacter) and Ruminococcaceae (p, Q eightfold higher abundance for Candidatus Stoquefichus and Tyzzerella (aRR = 8.8–12.8, p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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