Characterization of Natural Killer Cells and Cytokines in Maternal Placenta and Fetus of Diabetic Mothers
| Autor: | Cristiane de Castro Pernet Hara, Eduardo Luzía França, Danny Laura Gomes Fagundes, Adriele Ataides de Queiroz, Marilza Vieira Cunha Rudge, Adenilda Cristina Honorio-França, Iracema de Mattos Paranhos Calderon |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: | |
| Zdroj: | Journal of Immunology Research, Vol 2016 (2016) |
| Druh dokumentu: | article |
| ISSN: | 2314-8861 2314-7156 |
| DOI: | 10.1155/2016/7154524 |
| Popis: | The present study characterized natural killer cells and cytokines in diabetic mothers, their placenta, and fetus. In the maternal blood from the hyperglycemic groups, the CD16+CD56− NK cells increased, whereas that of CD16+CD56+ decreased in gestational diabetes mellitus [GDM] group. Cord blood from type 2 diabetes [DM-2] showed a higher proportion of CD16+CD56− and CD16−CD56+. The placental extravillous layer of GDM and DM-2 showed an increase of CD16+CD56− cells and, irrespective of region, the proportion of CD16−CD56+ cells was higher in mild gestational hyperglycemia [MGH] and GDM and lower in DM-2. IL-2 was lower in maternal blood and IFN-γ higher in maternal and cord blood from the GDM group. IL-17 was higher in maternal and cord blood from the DM-2 group. The placental extravillous layer of the MGH showed high levels of IL-4, IL-6, IL-10, IL-17, and IFN-γ and low levels of IL-1β and IL-8, whereas the placental villous layer contained high levels of IL-17 and IFN-γ. The GDM group, irrespective of region, showed higher levels of IL-8. The DM-2 group, irrespective of region, placenta showed high levels of TNF-α, IL-17, and IFN-γ. The hyperglycemia produces an inflammatory environment with a high content of inflammatory cytokines and cells expressing CD16+. |
| Databáze: | Directory of Open Access Journals |
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