Synthesis and Antimicrobial Studies of Coumarin-Substituted Pyrazole Derivatives as Potent Anti-Staphylococcus aureus Agents

Autor:	Rawan Alnufaie, Hansa Raj KC, Nickolas Alsup, Jedidiah Whitt, Steven Andrew Chambers, David Gilmore, Mohammad A. Alam
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	pyrazole coumarin antimicrobial hydrazone biofilm Staphylococcus aureus Organic chemistry QD241-441
Zdroj:	Molecules, Vol 25, Iss 12, p 2758 (2020)
Druh dokumentu:	article
ISSN:	1420-3049
DOI:	10.3390/molecules25122758
Popis:	In this paper, synthesis and antimicrobial studies of 31 novel coumarin-substituted pyrazole derivatives are reported. Some of these compounds have shown potent activity against methicillin-resistant Staphylococcus aureus (MRSA) with minimum inhibitory concentration (MIC) as low as 3.125 µg/mL. These molecules are equally potent at inhibiting the development of MRSA biofilm and the destruction of preformed biofilm. These results are very significant as MRSA strains have emerged as one of the most menacing pathogens of humans and this bacterium is bypassing HIV in terms of fatality rate.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/32f7c6dd7fcb499aa032bdb50270242e Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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