Genome-wide association study meta-analysis of blood pressure traits and hypertension in sub-Saharan African populations: an AWI-Gen study

Autor: Surina Singh, Ananyo Choudhury, Scott Hazelhurst, Nigel J. Crowther, Palwendé R. Boua, Hermann Sorgho, Godfred Agongo, Engelbert A. Nonterah, Lisa K. Micklesfield, Shane A. Norris, Isaac Kisiangani, Shukri Mohamed, Francesc X. Gómez-Olivé, Stephen M. Tollman, Solomon Choma, J-T. Brandenburg, Michèle Ramsay
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-023-44079-0
Popis: Abstract Most hypertension-related genome-wide association studies (GWASs) focus on non-African populations, despite hypertension (a major risk factor for cardiovascular disease) being highly prevalent in Africa. The AWI-Gen study GWAS meta-analysis for blood pressure (BP)-related traits (systolic and diastolic BP, pulse pressure, mean-arterial pressure and hypertension) from three sub-Saharan African geographic regions (N = 10,775), identifies two novel genome-wide significant signals (p
Databáze: Directory of Open Access Journals