Early postpartum abnormal glucose metabolism subtype differs according to mid-trimester lipid profile in women with gestational diabetes mellitus

Autor: Fenghua Lai, Zeting Li, Shufan Yue, Ling Pei, Huangmeng Xiao, Zhuyu Li, Yanbing Li, Haipeng Xiao, Xiaopei Cao
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Lipids in Health and Disease, Vol 20, Iss 1, Pp 1-9 (2021)
Druh dokumentu: article
ISSN: 1476-511X
DOI: 10.1186/s12944-021-01519-4
Popis: Abstract Background It is unknown whether early postpartum abnormal glucose metabolism (AGM) in women with previous gestational diabetes mellitus (GDM) is related to their mid-trimester lipid profile. The aim of this study was to characterize the mid-trimester lipid profile of women who experienced GDM and developed into different pathophysiologic subtypes of early postpartum AGM. Methods A retrospective cohort study of 498 women with history of GDM was conducted. A 75-g oral glucose tolerance test (OGTT) and plasma lipid measurements were performed at 24–28 weeks of gestation and 6–12 weeks of postpartum. Insulin secretion and sensitivity were estimated using early postpartum OGTT-based indices. Results Women in the mid-trimester dyslipidemia group had higher postpartum 30-min and 2-h plasma glucose, higher postpartum 2-h plasma insulin, higher postpartum triglyceride (TG), higher postpartum low density lipoprotein cholesterol (LDL-c) concentrations, lower postpartum 30-min insulinogenic index (IGI30), lower postpartum insulin sensitivity index (ISI), and lower postpartum disposition index than those in the normal lipid group (all P
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