Clinical parameters and inflammatory biomarkers among patients with multibracket appliances: a prospective clinical trial

Autor: Priscila Ferrari Peron, Heinrich Wehrbein, Ambili Mundethu, Irene Schmidtmann, Christina Erbe
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: BMC Oral Health, Vol 24, Iss 1, Pp 1-10 (2024)
Druh dokumentu: article
ISSN: 1472-6831
DOI: 10.1186/s12903-024-03995-3
Popis: Abstract Background Aim of the presented study was to investigate changes in clinical parameters and active matrix metalloproteinase-8 (aMMP-8) levels in gingival crevicular fluid of patients before and during treatment with multibrackets appliances. Methods Fifty-five adolescents scheduled for the treatment were included. Clinical parameters and subgingival samples were obtained at six time points: 1 week before appliance insertion (T0), 3 (T1), 6 (T2) weeks, 3 (T3), 6 (T4) months, and 1 year (T5) after that. Gingival index and plaque index were assessed to evaluated changes on the clinical status. Subgingival samples were collected to analyze changes in aMMP-8. Results Scores for gingival and plaque index increased after bracket insertion. The gingival index increased from T2 (p
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