EXPRESS METHOD FOR DETERMINATION OF ENALAPRIL AND ENALAPRILAT IN HUMAN SERUM BY HPLC-MS/MS
| Autor: | T. A. Rodina, E. S. Melnikov, S. A. Belkov, A. V. Sokolov, A. B. Prokofiev, A. S. Sivkov |
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| Jazyk: | ruština |
| Rok vydání: | 2019 |
| Předmět: | |
| Zdroj: | Разработка и регистрация лекарственных средств, Vol 0, Iss 4, Pp 184-189 (2019) |
| Druh dokumentu: | article |
| ISSN: | 2305-2066 2658-5049 |
| Popis: | The express method for simultaneous determination of enalapril and enalaprilat in human serum using HPLC-MS/MS is proposed. A simple sample preparation procedure, short analysis time, and a wide analytical range for both analytes (5.00 to 250.00 ng/mL) characterize this method. This technique is useful for carrying out routine research, such as therapeutic drug monitoring, bioequivalence studies and evaluation of the interchangeability of enalapril drug products. |
| Databáze: | Directory of Open Access Journals |
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