Predicting Long Term Outcome in Patients Treated With Continuous Flow Left Ventricular Assist Device: The Penn—Columbia Risk Score

Autor: Edo Y. Birati, Thomas C. Hanff, Dawn Maldonado, E. Wilson Grandin, Peter J. Kennel, Jeremy A. Mazurek, Esther Vorovich, Matthew Seigerman, Jessica L.L. Howard, Michael A. Acker, Yoshifumi Naka, Joyce Wald, Lee R. Goldberg, Mariell Jessup, Pavan Atluri, Kenneth B. Margulies, P. Christian Schulze, J. Eduardo Rame
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 7, Iss 6 (2018)
Druh dokumentu: article
ISSN: 2047-9980
DOI: 10.1161/JAHA.117.006408
Popis: BackgroundPredicting which patients are unlikely to benefit from continuous flow left ventricular assist device (LVAD) treatment is crucial for the identification of appropriate patients. Previously developed scoring systems are limited to past eras of device or restricted to specific devices. Our objective was to create a risk model for patients treated with continuous flow LVAD based on the preimplant variables. Methods and ResultsWe performed a retrospective analysis of all patients implanted with a continuous flow LVAD between 2006 and 2014 at the University of Pennsylvania and included a total of 210 patients (male 78%; mean age, 56±15; mean follow‐up, 465±486 days). From all plausible preoperative covariates, we performed univariate Cox regression analysis for covariates affecting the odds of 1‐year survival following implantation (P
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